The Her2/Neu (c-erbB-2) proto-oncogene is a transmembrane receptor tyrosine kinase that is clinically indicated in a number of carcinomas. Overexpression of theHer2/Neu protein has been associated with ductal breast cancer, as well as pulmonary and gastric adenocarcinomas. A correlation between Her2/Neu and p53 has also been documented, as overexpression of both proteins has been associated with early invasion and metastasis in bladder cancer.The Her2/Neu (IHC002-1) antibody is intended for qualified laboratories to identify by light microscopy the presence of associated antigens in sections of formalin-fixed, paraffin-embedded tissue sections using IHC test methods.